Control of Lipid Accumulation in the Yeast Yarrowia lipolytica
نویسندگان
چکیده
منابع مشابه
Lipid accumulation, lipid body formation, and acyl coenzyme A oxidases of the yeast Yarrowia lipolytica.
Yarrowia lipolytica contains five acyl-coenzyme A oxidases (Aox), encoded by the POX1 to POX5 genes, that catalyze the limiting step of peroxisomal beta-oxidation. In this study, we analyzed morphological changes of Y. lipolytica growing in an oleic acid medium and the effect of POX deletions on lipid accumulation. Protrusions involved in the uptake of lipid droplets (LDs) from the medium were ...
متن کاملSnf1 is a regulator of lipid accumulation in Yarrowia lipolytica.
In the oleaginous yeast Yarrowia lipolytica, de novo lipid synthesis and accumulation are induced under conditions of nitrogen limitation (or a high carbon-to-nitrogen ratio). The regulatory pathway responsible for this induction has not been identified. Here we report that the SNF1 pathway plays a key role in the transition from the growth phase to the oleaginous phase in Y. lipolytica. Strain...
متن کاملTranscriptomic Analyses during the Transition from Biomass Production to Lipid Accumulation in the Oleaginous Yeast Yarrowia lipolytica
We previously developed a fermentation protocol for lipid accumulation in the oleaginous yeast Y. lipolytica. This process was used to perform transcriptomic time-course analyses to explore gene expression in Y. lipolytica during the transition from biomass production to lipid accumulation. In this experiment, a biomass concentration of 54.6 g(CDW)/l, with 0.18 g/g(CDW) lipid was obtained in ca...
متن کاملLipids and lipid domains in the peroxisomal membrane of the yeast Yarrowia lipolytica.
Biological membranes have unique and highly diverse compositions of their lipid constituents. At present, we have only partial understanding of how membrane lipids and lipid domains regulate the structural integrity and functionality of cellular organelles, maintain the unique molecular composition of each organellar membrane by orchestrating the intracellular trafficking of membrane-bound prot...
متن کاملRecent advances in bioengineering of the oleaginous yeast Yarrowia lipolytica
The oleaginous yeast, Yarrowia lipolytica, is becoming increasing popular for metabolic engineering applications. Advances in synthetic biology and metabolic engineering have allowed microorganisms such as Y. lipolytica to be tailored for specific chemical production. Significant progress has been made to understand the genetics of Y. lipolytica and towards developing novel genetic engineering ...
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ژورنال
عنوان ژورنال: Applied and Environmental Microbiology
سال: 2008
ISSN: 0099-2240,1098-5336
DOI: 10.1128/aem.01412-08